A Demon Lord’s Tale: Dungeons, Monster Girls, and Heartwarming Bliss - Chapter 548

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7. Hypertrophie vs hypertrophie musculaire

   The penalties for illegally administering steroids varies for each Australian state and territory.
   If you’re injecting steroids, you’re additionally susceptible to contracting blood-borne viruses such as HIV, tetanus or Hepatitis C or
   B. Men and boys with muscle dysmorphia (a sort of body dysmorphic disorder) see themselves as not
   muscular sufficient and may abuse steroids in a bid to repair
   this perceived flaw. The purpose there are so many decisions is
   as a result of every steroid is catered to every of those specific
   targets. If you’re like most individuals and need results
   FAST, then this final stack may be the one for you! It combines all the benefits and advantages
   of the bulking, chopping and strength gain stacks into one super,
   extremely, mega stack. It is often used to deal with
   asthma due to its capability to open up the bronchial muscular tissues.

   If the increase indeed is causal, it remains to be determined
   whether or not this displays a true decrease in GFR or whether AAS affect serum cystatin C concentrations by other means.
   Future research would possibly assist reply this query by comparison with more
   correct (though much less convenient) GFR filtration markers similar to iohexol or iothalamate.
   As with different unwanted effects, some AAS users self-medicate to mitigate
   this unfavorable shift in lipid profile. This contains both dietary supplements, such as niacin, red yeast rice extract and berberine, but also prescription medication similar to
   statins. Niacin raises HDL-cholesterol, but has no impact on general
   mortality, cardiovascular mortality, non-cardiovascular mortality, the variety of fatal or non-fatal myocardial infarctions,
   nor the number of deadly or non-fatal strokes (134).
   Besides its side effects, its use may result in underestimation of CVD danger when utilizing danger algorithms which are guided by HDL-cholesterol levels.

   This has led to elevated efforts by legislation enforcement and sports activities organizations to fight the use of performance-enhancing
   medicine. forty nine.8% of boys reported current use of, and 62% intended to make use of protein powder; eight.4% used creatine, and four.2% used anabolic steroids.
   In Victoria, Australia, the use of steroids is strictly regulated underneath the Medication, Poisons, and Managed Substances Act 1981.

   In doing so, you will need to take notice of blood strain cuff size.
   AAS users are extra doubtless to have giant higher arm circumferences, and an inappropriately small cuff
   will overestimate blood strain. The significance of using an appropriate cuff measurement
   in a muscular population was underscored in a trial analyzing blood
   pressure in a cohort of competitive bodybuilders (96). In these with an upper arm circumference
   greater than 33 cm, systolic blood stress was 8.2 mmHg larger utilizing cuff
   dimension M in contrast with cuff size L. As a outcome, 33% of the themes would be categorised as hypertensive utilizing the – inappropriate – cuff size M,
   whereas solely 12% could be categorized as such using cuff dimension L.

   LVEF decreased by 5%-point and left atrium quantity, LV mass, posterior wall thickness and
   interventricular septum thickness have been increased at the end of the AAS cycle (Figure 6).
   The ratio of early (E) to late (A) ventricular filling velocity, or
   E/A ratio, decreased by zero.forty five. Nevertheless, this doesn’t
   preclude the chance that these adjustments may become everlasting with more prolonged AAS use or with repeated cycles that present too little time for recovery to happen in between. This is particularly worrisome as there’s appreciable proof that myocardial damage, which can accumulate in years of ongoing AAS use, is a major cause for sudden cardiac death in AAS customers (217).
   Not solely will you lose a number of the changes to your appearance and performance,
   but you’ll also expertise symptoms of low testosterone.

   These medication are based on testosterone and other androgenic steroid
   hormones corresponding to nandrolone and dihydrotestosterone
   (DHT). Bodybuilders often overlook that they are taking super dangers when utilizing these substances,
   even if it is to extend muscle mass. If you’re
   in search of secure and efficient steroids in Australia, you’ve come to the proper
   place! Our online anabolic shop makes a speciality of delivering steroids across
   Australia. Half of the testosterone is converted to estrogen (as talked about
   above), and a few synthetic androgens trigger such side effects as gynecomastia,
   increased tissue behind the nipple (commonly known as man boobs).
   It generally looks naturally maturing in teenagers,
   and a small portion of males.
   It can provide large muscle and energy positive aspects twice as quick, generally even overnight!
   However all of it comes at a giant trade-off, as Anadrol can be
   one of the riskiest to your health. These can be within the type of liver
   injury, breast progress (not good), shrinking of testicles (definitely not
   good!) and high blood pressure, amongst others. Human Progress
   Hormone (HGH) is far more than a muscle-builder it’s a total-body enhancer.
   With wide-ranging results from fat loss to pores and skin improvement, HGH is
   well-liked with athletes, bodybuilders, and wellness enthusiasts alike.
   If injections aren’t your factor, oral steroids supply a easy but effective method to
   kickstart your fitness journey.
   Whereas they can be prescribed for certain medical conditions—such as
   hormone deficiencies—they are sometimes misused for efficiency enhancement or aesthetic features.
   Steroid abuse typically involves huge doses of illegally sourced drugs, that provide a vastly greater level of hormones than required for reliable testosterone alternative therapy.
   DecaDuro is the authorized steroid to switch, you guessed it,
   Deca-durabolin.
   It can additionally be an offence to possess anabolic steroids with intent to
   supply or sell to another, manufacture or prepare anabolic steroids, or sell or supply
   anabolic steroids, including providing to do so.
   There is a comprehensive list of drugs categorised as ‘steroid drugs’ under Schedule 1, Half
   2 of the Medicine Misuse Regulation 1987 (QLD).
   This contains testosterone, trestolone, androstenediol,
   drostanolone, ethyldienolone, and some other anabolic and androgenic steroidal agent.

   References:

   Hypertrophie vs hypertrophie musculaire

   November 1, 2025 at 6:00 am

   Reply
8. Albuterol for Chronic Bronchial Conditions

   Developments for a main impact had been current for ND to increase
   ACTA1 mRNA expression at forty two days in eight-week-old male C57BL/6 mice
   (38). These findings recommend a rather high proportion of former
   AAS abusers exhibit testosterone levels in the low area of the normal vary years after AAS cessation, whereas only a small proportion of former AAS abusers exhibit persistently marked low testosterone levels.
   Former AAS abusers exhibited significantly decrease plasma testosterone levels and
   better frequencies of signs suggestive of hypogonadism than healthy control individuals years after AAS cessation.
   Discussions exist as to how the endogenous testosterone and spermatogenic functions of
   the testes are inhibited by means of testosterone and AASs.
   The seminal vesicles and ventral prostate are tissues that comprise excessive levels of androgen receptors and are overly
   sensitive to androgenic results. Any development
   in these tissues would indicate the ability of a compound to exert androgenic effects.
   The price of progress in these tissues can be used to determine the androgenic score of the steroid being observed.
   As we delve deeper into the realm of anabolic steroids, it’s essential
   to differentiate between anabolic, androgenic, and estrogenic properties.
   Each of these terms represents a special facet of
   how these substances affect the body, and understanding their differences may help you make informed
   decisions. Individuals who are serious about taking anabolic steroids ought to rigorously contemplate
   each the effects they need and the results they may have.

   The first step in treating anabolic steroid dependency is to discontinue use and search medical assist.
   For instance, corticosteroids may help individuals with asthma breathe by reducing irritation within the airways.
   According to the Nationwide Institute on Drug Abuse (NIDA),
   continuous use of AASs can lead to issues corresponding to tolerance, that
   means an individual wants larger doses to achieve the same
   effects. A Swedish national population-based cohort research discovered a
   cardiovascular morbidity and mortality price twice as high in individuals who examined positive
   for AAS use in contrast with those that tested negative (149).
   Similarly, a Danish retrospective matched cohort research
   discovered non-ischaemic coronary heart illness charges,
   corresponding to cardiomyopathy and atrial fibrillation, to be three times greater in those who tested positive for AAS use
   in contrast with matched controls (212).
   Classification of a facet effects’ probability relies on professional opinion of
   the authors. AAS are predominantly bioinactivated in the
   liver, but in addition within the kidneys and varied other androgen-sensitive tissues (25).
   In common, phase I metabolism mainly involves reduction at carbons 3 and 5 of the A-ring and oxidation of
   the hydroxyl group at carbon 17 of the D-ring of the steroid nucleus (24).
   These section I metabolites might then endure conjugation into glucuronides and be subsequently excreted (26).
   (A) Scenario of randomized response survey by which nobody in a gaggle of 20 makes use of AASs.

   If gonadotrophins, testosterone levels and testicular volume are normal, obstructive azoo-
   or oligospermia should be suspected. If gonadotrophins and testosterone
   levels are low, and other causes of hypogonadotrophic hypogonadism are explored and rejected, the wait-and-see policy ought to be continued for six extra months.
   If hypogonadotrophic hypogonadism and oligospermia persist,
   spermatogenesis and endogenous testosterone manufacturing may be stimulated by administration of hCG 1500 IU two to a few times weekly.
   Assuming that spermatogenesis has been regular
   in the pre-AAS period, hCG is effective in restoring spermatogenesis and endogenous testosterone ranges to normal levels (25).
   Anabolic steroids are mostly utilized in cycles with a length between 6 and 18 weeks.

   It should be famous that cuff size was adjusted based on higher arm circumference within the HAARLEM examine, and thus the
   results were not affected by this problem (46).
   The detrimental results of those seemingly small increases in blood pressure shouldn’t be underestimated.
   Whereas it is exhausting to estimate their impact on CVD danger, one might try to
   quantify it by looking on the – well-researched –
   results of blood pressure-lowering treatment. Each 10 mmHg reduction in systolic
   blood strain reduces the risk of major cardiovascular events,
   coronary coronary heart illness, stroke, heart failure, and all-cause mortality
   by 20%, 17%, 27%, 28%, and 13%, respectively (95).
   To tackle this, testosterone undecanoate has just lately been formulated in a self-emulsifying drug delivery system (SEDDS) to further
   improve lymphatic absorption and scale back intra- and interindividual variation (10).

   Nonetheless, it must be dosed twice day by day to take care of
   physiological testosterone ranges throughout the day.

   An different technique facilities around considerably retarding metabolism
   of the compound.
   Cytomel (T3) is used medically by individuals with an underactive thyroid, which might end up in weight achieve.

   T3, subsequently, assists with weight loss not directly by replacing this thyroid hormone.

   When utilized by athletes with a traditional functioning
   thyroid at a dose above what is of course produced by
   the thyroid, the metabolism is elevated, and fats burning turns into easier and faster.

   This is a veterinary steroid used on debilitated horses to extend urge for
   food and improve physique and muscle situation. EQ is a long-acting injectable steroid that has glorious
   anabolic properties and low androgenic exercise. Methenolone is a DHT-derived steroid out there in both oral and injectable forms, with the injectable
   known as Primobolan Depot.
   Whereas the strategies have been unscientific and poorly described, the first and solely examine to judge
   intimately the buying process of AAS over the Web with
   no prescription was a 2005 report from the USGAO (Cramer et al., 2005).
   Government investigators discovered “hundreds” of websites providing AAS for purchase and submitted 22 orders of which 14 shipped
   but only 10 really contained AAS substances.
   Related to the present findings, all AAS products had
   been bought using a bank card and delivered to house addresses using discreet, anonymous packaging from international pharmacies situated in Europe and Asia.
   Equally, a research from 2006 suggested that 35% of sites promoting AAS on the
   Internet did not require a prescription for purchase and 30% or 50% accepted money
   orders or credit cards Albuterol for Chronic Bronchial Conditions
   payment respectively, but the buy process was not rigorously evaluated (Clement et al., 2012).
   Interestingly, this research searched both Google and Yahoo search
   engines with no observed variations within the results (Clement et al., 2012).
   Only 11% of sites have been registered within the Usa, however all functioned as
   a “portal” to international pharmacies.
   Lipid profile, liver operate tests, hemoglobin, hematocrit,
   prostate-specific antigen (PSA), and prostate examination in sufferers older than forty years of age are needed earlier than initiating treatment.
   Irreversible changes embrace male-pattern baldness and breast improvement
   (gynecomastia) in men 96, ninety seven. Anabolic steroids may
   act upon the hormone system to increase the risk of testicular cancer, particularly when steroids
   are utilized in combination with insulin-like growth factor 98.

   November 1, 2025 at 6:41 am

   Reply
9. PedsElite

   The mechanism concerned in collagen deposition could probably be the rise within the number and within the activity of Kuppfer cells.
   In this regard, Kuppfer cell activation leads to the manufacturing of
   many inflammatory cytokines similar to TGF-b1, NF-Kb, IL-1b, associated to the liver fibrosis
   course of [85,86]. Recent scientific and experimental studies proved that
   the elevated exercise of the renin-angiotensin-aldosterone
   system (RAAS) performs a pivotal position within the pathogenesis of
   cardiological ailments.
   This side effect is usually solely short-term and will resolve once you stop
   taking Trenbolone. Thus, trenbolone will add extra lean muscle than Deca-Durabolin; nonetheless, weight acquire at the finish of a cycle could also be comparable due to Deca causing fluid retention and trenbolone enhancing fats loss (10).
   Some steroid users might try to stop gynecomastia when operating this cycle by administering an aromatase inhibitor (AI) to
   lower progesterone (not estrogen). Nevertheless, we discover this exacerbates cardiovascular
   pressure because of lower levels of estrogen. Moreover,
   Anadrol-induced gynecomastia remains a concern even when administering an AI.

   In this regard, additional studies are wanted to evaluate the epidemiology of delinquent behavior
   related to AAS assumption and the relationship with other drug consumption. Side
   effects of creatine can include gaining weight and cramps
   within the belly or muscles. There are “natural” dietary supplements legally sold over-the-counter which are marketed for athletic
   performance. Nonetheless, these are not regulated, they usually can still trigger unwanted effects.

   Additionally, you must discuss with a well being care provider in case you are misusing these steroids and you
   would possibly be feeling as though you would possibly have an addiction to them.
   They can suggest a remedy plan that will help you safely stop taking steroids
   whereas also addressing points that will assist you
   not use them sooner or later.
   Men who run Nandrolone cycles will almost all the time be delighted with the results.
   With Deca, we take the great with the bad, and it’s
   up to you whether or not the positives outweigh the downsides.
   These therapeutic advantages of Deca-Durabolin make it a really
   versatile steroid that you could embrace in any cycle,
   where a low dose can exclusively be used for joint and
   healing benefits. There are two intercourse
   hormones present in women and men, testosterone and estrogen,
   however each sex has more of one over the opposite. By far probably the
   most prevalent anabolic steroid prevention applications in the us are those aimed toward skilled,
   Olympic, and school athletes. Very few local college districts have established steroid
   prevention packages. There have been reviews of people that misuse steroids experiencing
   psychotic and manic reactions.
   As if that’s not sufficient, you will get away with no PCT and often no want for any ancillary compounds.
   Combining the first and secondary compounds into a regular cycle
   stack makes for a robust cycle. Nonetheless, relying in your experience degree, you might contemplate stacking extra compounds for extra important results.

   Ignorance of the regulation just isn’t a valid defense, and the consequences can be severe.
   PCT can help to mitigate a number of the unwanted aspect effects of Anavar,
   corresponding to hormonal imbalances and menstrual irregularities.
   Post-Cycle Therapy (PCT) is an important a half of the detoxing course of.
   PCT entails the utilization of medications to revive the
   body’s pure hormone balance after a cycle of Anavar.
   Brittany has 15 years of experience within the Mental Well Being and Substance Abuse field.

   Any change in therapy must be discussed with and supervised by a healthcare provider to make sure security and effectiveness.
   • Short-term results (e.g., fluid retention, increased appetite, mood
   changes) usually resolve shortly.• Long-term results
   (e.g., osteoporosis, cataracts, skin thinning) could additionally be long-lasting or permanent.
   A typical tapering plan would possibly involve lowering the steroid dose by small quantities every one to 2 weeks, with the speed of reduction slowing because the dose will get lower.
   This gradual approach helps minimize the risk of adrenal insufficiency and different withdrawal
   problems.
   Apparently, we have found anti-estrogens such as anastrozole to be
   efficient inhibitors of progesterone receptor expression and, consequently, scale back the danger of gynecomastia in our sufferers (4).
   We have additionally discovered Deca-Durabolin to increase collagen synthesis,
   enhancing the health of ligaments and tendons. This is especially helpful to bodybuilders and powerlifters who regularly raise heavy
   weights, making them extra prone to harm. If you endure
   from hypogonadism and require testosterone for medicinal purposes, we suggest Olympus Men’s testosterone alternative therapy
   (TRT) program.
   Even short?term use can elevate blood strain and shift cholesterol balance—raising LDL (“bad” cholesterol) whereas lowering
   HDL (“good” cholesterol). Those adjustments set the stage for coronary heart issues down the road, even when you feel
   nice now. Some steroid users expertise sudden, extreme bouts of aggression, commonly known as “roid rage”.[10] During this era, they may
   carry out violent acts that might otherwise be out of character.

   References:

   PedsElite

   November 1, 2025 at 7:29 am

   Reply
10. Réglementation française sur l'oxandrolone

    Components such as intercourse hormone-binding globulin (SHBG) levels can guide a doctor, however optimal
    dosing varies from daily to weekly. Sufferers
    with related dosing and blood ranges may still expertise totally different
    outcomes. Beware of clinics, doctors, coaches, or social media influencers claiming a one-sise-fits-all therapy protocol; this is probably a sales method
    rather than an accurate representation of the individualised nature of TRT.
    The testosterone propionate is out there completely to BALANCE
    MY HORMONES sufferers is 25mg of Testosterone Propionate in a single-use ampoule.
    Blood levels with 20mg daily injections have been 40nmo/L
    on the trough day or the following morning earlier than the next injection. For those that
    don’t wish to apply the cream day by day or twice day by day,
    or for those who choose daily or alternate-day injections, testosterone propionate could also be an excellent various.

    It comes in a single ampoule and sufficient ampoules are
    provided as an economical approach to do extra frequent
    injections.
    That can make this specific facet impact even worse than excessive estrogen. It’s not just what you
    use however the way you dose it along with your steroid dosage.

    In other words, there’s no single dose I can give you that “works” to
    prevent gyno. You might need to experiment early on till
    you get the stability proper. A daily Pramipexole dose between zero.125mg and zero.25mg is effective at preventing gyno, lactation, and sexual
    dysfunction brought on by excessive prolactin levels.
    The dosage may be as high as 25mg/daily, however most customers will discover 12.5mg day by day works nicely, with the
    final week of PCT dropping the dosage to half at 6.25mg/daily.

    If you’d like to make use of Enclomiphene for PCT, check
    out my in-depth Enclomiphene PCT information.
    Dosage varies primarily based on what your targets are and how experienced and confident you are in utilizing steroids and
    controlling side effects. Most bodybuilders will use round 500mg each week of
    testosterone cypionate for bulking functions. Some will begin as little as 200mg or 300mg
    weekly, while hardcore bodybuilders are recognized to
    extend right as much as 1000mg per week. It has an extended half-life, so you will get away with
    taking your whole dose in just one injection every week.
    Nonetheless, ideally, you must split your weekly dosage into two and inject
    testosterone cypionate twice weekly so that you assure ranges of the steroid keep excessive.
    Testosterone Cypionate will stack nicely
    with another anabolic steroid.
    And, for us bodybuilders, it’s the anabolic steroid category that serves our needs.
    When frontloading, you’ll twice or even triple your regular dose inside the first week or so of using the steroid.
    This lets you reap the benefits of the natural quick spike in hormone launch upon injection, which slows down afterward and becomes extra gradual.
    Frontloading will amplify this initial impact early on and allow you to benefit sooner from increased efficiency.
    As bodybuilders who use steroids, certainly one of our highest
    priorities is to maintain up a excessive and constant blood plasma
    stage of all steroids being used in a cycle. When you’re using one of
    many slow appearing (long ester) steroids, it leads to a slower
    build-up of the steroid over a longer period and, due to this fact, slower results.

    It additionally raises the chance of a situation that keeps
    the brain from getting enough oxygen, known as a stroke.

    Biochemically, this expresses itself in relatively small elevations of
    blood aspartate aminotransferase (AST), alanine aminotransferase (ALT),
    lactate dehydrogenase (LDH) and gamma-glutamyl transpeptidase (GGT) (99) values.

    Not Often, AAS-induced hepatotoxicity may present itself in jaundice and pruritus (100, 101).

    With such scientific presentations, elevated bilirubin values are additionally to be
    anticipated. Other stories in literature have additionally documented peliosis hepatis (102, 103), hepatocellular carcinoma (104) and
    adenoma (105, 106) in affiliation with AAS use. The incidence is probably (very) low and a agency
    causal hyperlink has not been established. Inside the cell, it
    could both bind directly to the androgen receptor (AR)
    to affect gene expression or endure bioactivation into dihydrotestosterone (DHT)
    by 5?R-reductase (5?R) household enzymes or estradiol (E2) by aromatase.

    However you won’t necessarily ever have to take 20mg if
    you’re seeing wonderful outcomes at 10mg or even 15mg.
    Always start on the lowest dosage recommendation, evaluate your response,
    after which increase the dosage when you respond nicely and
    need more powerful outcomes. However if you’re new to all
    this, you might be shocked to learn that Anavar is derived from DHT.
    Despite this, Anavar does NOT include the potent androgenic unwanted effects
    of most different DHT-derived steroids. A week commonplace cycle ought to provide you with two cycles every year with sufficient recovery
    time in between. If you’re going to do recurring cycles,
    your off-cycle time should be no less than equal to the length of the cycle itself.
    This permits a full HPTA restoration (aided by PCT)
    and a sufficient break from all steroids earlier than getting back to
    another cycle.
    Anabolic–androgenic steroids (AAS) are a class of pure and synthetic hormones that owe
    their name to their chemical construction (the steroid nucleus, see Figure 1) and the organic results (anabolic and
    androgenic) they induce. Testosterone is the primary endogenous hormone belonging to this class.
    It is widely used therapeutically, in various esterified types, as substitute remedy in male hypogonadism.
    Testosterone, and a select few other AAS corresponding to nandrolone
    and oxandrolone, may also be prescribed for different medical circumstances (e.g., osteoporosis or aplastic anemia).
    Apart From this legitimate medical use, AAS are
    extensively used – or rather, abused – for their muscle-building
    and strength-increasing properties in dosages far exceeding
    those used therapeutically.
    Fertility could also be impaired on account of the suppressive effects of
    AAS on gonadotropin production, causing disruption of the menstrual cycle.
    In addition, AAS have virilizing effects, which obviously isn’t an issue
    in men but has great medical significance in women. These effects include dysphonia or deepening of the voice, hirsutism and
    clitoromegaly.

    References:

    Réglementation française sur l’oxandrolone

    November 1, 2025 at 7:46 am

    Reply